Nicole recommends Zita the Spacegirl by Ben Hatke

The fast-paced, imaginative adventures of
Zita the Spacegirl remind me of Calvin's alter-ego Spaceman Spiff in
Calvin & Hobbes. Zita fearlessly travels through a galaxy of unusual aliens in order to save her friend Joseph.
Publisher's description
When young Zita discovers a device that opens a portal to another place, and her best friend is abducted, she is compelled to set out on a strange journey from star to star in order to get back home.